Pharma Franchise, Pharma PCD & Third party manufacturing of Quinolone Drugs
Quinolones act by the rapid inhibition of bacterial DNA synthesis, leading to cell death. The primary targets are DNA gyrase and topoisomerase IV which are involved in the maintenance of the superhelical structure of DNA. Quinolones are one of the most commonly prescribed classes of antibacterials in the world and are used to treat a variety of bacterial infections in humans. Because of the wide use (and overuse) of these drugs, the number of quinolone-resistant bacterial strains has been growing steadily since the 1990s. As is the case with other antibacterial agents, the rise in quinolone resistance threatens the clinical utility of this important drug class.
Quinolones and fluoroquinolones are considered broad-spectrum antibiotics. This means that they are effective against a wide range of bacteria.
However, because of their risk of serious side effects, the FDA has advised that they should only be used to treat conditions such as sinusitis, bronchitis, and uncomplicated urinary tract infections when other, less toxic antibiotics are not appropriate.
Quinolones and fluoroquinolones may also be used to treat unusual infections such as anthrax or plague. Doctors may also decide to use them for other types of infection when other alternative treatment options have failed or cannot be used.